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KMID : 0603820100160030139
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Journal of Experimental & Biomedical Science
2010 Volume.16 No. 3 p.139 ~ p.149
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An Acute Pathophysiology of Environmental Strains of Cryptococcus neoformans Isolated from a Park in Busan
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Choi Seok-Cheol
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Abstract
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The present study was carried out to elucidate whether an environmental strain of Cryptococcus neoformans (environmental C. neoformans) isolated from an environmental source in a park of Busan has an acute pathophysiological effect in rats. On the second day after peritoneal inoculation of environmental C. neoformans, adverse effects occurred from the viewpoint of hematology and biochemistry. Eosinophil damages and crystal formations were found in the blood. Disturbances in cytokines production were observed in the cerebral and pulmonary tissues. Fungal budding existed in the brain, lung, liver and kidney. Tissue injury findings such as inflammation, leukocyte infiltration, bleeding, or degeneration were found in the brain, lung, liver and kidney. The present data suggest that the environmental C. neoformans can cause systematically harmful effects even for short periods of infection (two days of cryptococcal infection) and the adverse effects are summarized as immune derangements and biochemical and/or histological dysfunction and injury on major organ such as the brain, lung, liver and kidney in the immunocompetent hosts. Further studies should be focused on comparing the differences between environmental and clinical strains of C. neoformans.
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KEYWORD
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Environmental strain of C. neoformans, Eosinophil, Crystal formation, Acute organ injury, Cytokines
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